Identification of a functional connectome for long-term fear memory in mice.
Identifieur interne : 000D59 ( Main/Exploration ); précédent : 000D58; suivant : 000D60Identification of a functional connectome for long-term fear memory in mice.
Auteurs : Anne L. Wheeler [Canada] ; Cátia M. Teixeira ; Afra H. Wang ; Xuejian Xiong ; Natasa Kovacevic ; Jason P. Lerch ; Anthony R. Mcintosh ; John Parkinson ; Paul W. FranklandSource :
- PLoS computational biology [ 1553-7358 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- physiology : Brain.
- Animals, Fear, Immunohistochemistry, Memory, Mice, Mice, Mutant Strains, Nerve Net.
Abstract
Long-term memories are thought to depend upon the coordinated activation of a broad network of cortical and subcortical brain regions. However, the distributed nature of this representation has made it challenging to define the neural elements of the memory trace, and lesion and electrophysiological approaches provide only a narrow window into what is appreciated a much more global network. Here we used a global mapping approach to identify networks of brain regions activated following recall of long-term fear memories in mice. Analysis of Fos expression across 84 brain regions allowed us to identify regions that were co-active following memory recall. These analyses revealed that the functional organization of long-term fear memories depends on memory age and is altered in mutant mice that exhibit premature forgetting. Most importantly, these analyses indicate that long-term memory recall engages a network that has a distinct thalamic-hippocampal-cortical signature. This network is concurrently integrated and segregated and therefore has small-world properties, and contains hub-like regions in the prefrontal cortex and thalamus that may play privileged roles in memory expression.
DOI: 10.1371/journal.pcbi.1002853
PubMed: 23300432
Affiliations:
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Wang</name></author><author><name sortKey="Xiong, Xuejian" sort="Xiong, Xuejian" uniqKey="Xiong X" first="Xuejian" last="Xiong">Xuejian Xiong</name></author><author><name sortKey="Kovacevic, Natasa" sort="Kovacevic, Natasa" uniqKey="Kovacevic N" first="Natasa" last="Kovacevic">Natasa Kovacevic</name></author><author><name sortKey="Lerch, Jason P" sort="Lerch, Jason P" uniqKey="Lerch J" first="Jason P" last="Lerch">Jason P. Lerch</name></author><author><name sortKey="Mcintosh, Anthony R" sort="Mcintosh, Anthony R" uniqKey="Mcintosh A" first="Anthony R" last="Mcintosh">Anthony R. Mcintosh</name></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name></author><author><name sortKey="Frankland, Paul W" sort="Frankland, Paul W" uniqKey="Frankland P" first="Paul W" last="Frankland">Paul W. Frankland</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23300432</idno><idno type="pmid">23300432</idno><idno type="doi">10.1371/journal.pcbi.1002853</idno><idno type="wicri:Area/PubMed/Corpus">000995</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000995</idno><idno type="wicri:Area/PubMed/Curation">000995</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000995</idno><idno type="wicri:Area/PubMed/Checkpoint">000995</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000995</idno><idno type="wicri:Area/Ncbi/Merge">001349</idno><idno type="wicri:Area/Ncbi/Curation">001349</idno><idno type="wicri:Area/Ncbi/Checkpoint">001349</idno><idno type="wicri:Area/Main/Merge">000D70</idno><idno type="wicri:Area/Main/Curation">000D59</idno><idno type="wicri:Area/Main/Exploration">000D59</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of a functional connectome for long-term fear memory in mice.</title><author><name sortKey="Wheeler, Anne L" sort="Wheeler, Anne L" uniqKey="Wheeler A" first="Anne L" last="Wheeler">Anne L. Wheeler</name><affiliation wicri:level="1"><nlm:affiliation>Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Teixeira, Catia M" sort="Teixeira, Catia M" uniqKey="Teixeira C" first="Cátia M" last="Teixeira">Cátia M. Teixeira</name></author><author><name sortKey="Wang, Afra H" sort="Wang, Afra H" uniqKey="Wang A" first="Afra H" last="Wang">Afra H. Wang</name></author><author><name sortKey="Xiong, Xuejian" sort="Xiong, Xuejian" uniqKey="Xiong X" first="Xuejian" last="Xiong">Xuejian Xiong</name></author><author><name sortKey="Kovacevic, Natasa" sort="Kovacevic, Natasa" uniqKey="Kovacevic N" first="Natasa" last="Kovacevic">Natasa Kovacevic</name></author><author><name sortKey="Lerch, Jason P" sort="Lerch, Jason P" uniqKey="Lerch J" first="Jason P" last="Lerch">Jason P. Lerch</name></author><author><name sortKey="Mcintosh, Anthony R" sort="Mcintosh, Anthony R" uniqKey="Mcintosh A" first="Anthony R" last="Mcintosh">Anthony R. Mcintosh</name></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name></author><author><name sortKey="Frankland, Paul W" sort="Frankland, Paul W" uniqKey="Frankland P" first="Paul W" last="Frankland">Paul W. Frankland</name></author></analytic><series><title level="j">PLoS computational biology</title><idno type="eISSN">1553-7358</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (physiology)</term><term>Fear</term><term>Immunohistochemistry</term><term>Memory</term><term>Mice</term><term>Mice, Mutant Strains</term><term>Nerve Net</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Fear</term><term>Immunohistochemistry</term><term>Memory</term><term>Mice</term><term>Mice, Mutant Strains</term><term>Nerve Net</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Long-term memories are thought to depend upon the coordinated activation of a broad network of cortical and subcortical brain regions. However, the distributed nature of this representation has made it challenging to define the neural elements of the memory trace, and lesion and electrophysiological approaches provide only a narrow window into what is appreciated a much more global network. Here we used a global mapping approach to identify networks of brain regions activated following recall of long-term fear memories in mice. Analysis of Fos expression across 84 brain regions allowed us to identify regions that were co-active following memory recall. These analyses revealed that the functional organization of long-term fear memories depends on memory age and is altered in mutant mice that exhibit premature forgetting. Most importantly, these analyses indicate that long-term memory recall engages a network that has a distinct thalamic-hippocampal-cortical signature. This network is concurrently integrated and segregated and therefore has small-world properties, and contains hub-like regions in the prefrontal cortex and thalamus that may play privileged roles in memory expression.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Frankland, Paul W" sort="Frankland, Paul W" uniqKey="Frankland P" first="Paul W" last="Frankland">Paul W. Frankland</name><name sortKey="Kovacevic, Natasa" sort="Kovacevic, Natasa" uniqKey="Kovacevic N" first="Natasa" last="Kovacevic">Natasa Kovacevic</name><name sortKey="Lerch, Jason P" sort="Lerch, Jason P" uniqKey="Lerch J" first="Jason P" last="Lerch">Jason P. Lerch</name><name sortKey="Mcintosh, Anthony R" sort="Mcintosh, Anthony R" uniqKey="Mcintosh A" first="Anthony R" last="Mcintosh">Anthony R. Mcintosh</name><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><name sortKey="Teixeira, Catia M" sort="Teixeira, Catia M" uniqKey="Teixeira C" first="Cátia M" last="Teixeira">Cátia M. Teixeira</name><name sortKey="Wang, Afra H" sort="Wang, Afra H" uniqKey="Wang A" first="Afra H" last="Wang">Afra H. Wang</name><name sortKey="Xiong, Xuejian" sort="Xiong, Xuejian" uniqKey="Xiong X" first="Xuejian" last="Xiong">Xuejian Xiong</name></noCountry><country name="Canada"><noRegion><name sortKey="Wheeler, Anne L" sort="Wheeler, Anne L" uniqKey="Wheeler A" first="Anne L" last="Wheeler">Anne L. Wheeler</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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